The Delta Theory: The True Nature of Disease Causation

Delta has proposed a new theory on disease causation that attempts to explain the vast majority of chronic conditions.  This theory describes the vast majority of chronic degenerative conditions, such as cancer, arthritis, cardiovascular, neurodegenerative, autoimmune, and many other conditions as mitochondrial dysfunctions in energy metabolism.

The Theory of causation places emphasis on recognizing factors directly responsible for impairment at the level of causation, such as NADH co-Q Reductase Deficiencies brought about by microbial unsaturated proteins and chemical structures that block electron transport in the mitochondrial membrane, this impairing ATP production.

Moreover, Delta asserts that any meaningful theory on causation must separate the mechanisms of impairment from other factors that may be viewed as either correlative variables, or pre disposing factors, which Delta believes must be thoroughly understood to achieve a comprehensive framework for understanding the diverse attributes of chronic pathologies.

Three factors that must be considered in order to conceptualize the complexities of chronic disease are:

  • pre disposing factors
  • correlative variables
  • mechanisms of impairment  


Pre disposing factors 

These factors pertain to conditions that may prepare a system for integration or enhance or facilitate a mechanism of impairment. They contribute to causation by weakening the body’s ability to defend itself against toxins and microbes. Pre-disposing factors are often represented as mechanisms for impairment when in fact they are not.

One of the most common phrases in medicine today is the medical term “unknown etiology”. This lack of certainty about what actually establishes a disease state leads many to mistakenly view predisposing factors as causative in nature when in fact they are merely precursors to disease.  Admittedly, these factors are readily identifiable, and when addressed can contribute to an improvement in the condition despite the fact that the cause has not been addressed.

Illustratively, imagine your vehicle breaking down and the mechanic says “ah ha, you have bad fuel. That’s the cause of your vehicle failure”. So you change the fuel out and the vehicle performance improves. However, a knock in the engine catches your attention and you decide to take your BMW to the old German down the street who says: “Yes, your fuel was a predisposing factor but the actual mechanism of impairment is a lack of compression due to the fact that the carbon deposits brought about by the bad fuel caused the piston rings to wear out and now your fuel and air is not getting compressed properly”. He proceeds to install new seals and your back to normal.  Now, there is no problem with changing out the fuel, but until the impairment was identified and addressed, the potential for a complete fix was missing.

Examples of Pre disposing factors could include:

  • Genetics
  • Epigenetics
  • Immunodeficiency
  • Environmental 
  • Nutritional
  • Hyperacidity
  • Hypoxia
  • Microbial Precursors
  • Infections
  • Mold
  • Heavy Metals


One example relates to a doctor claiming that hyperacidity causes chronic disease, as opposed to viewing hyperacidity as a means to an end, or a predisposing factor, that facilitates bacterial overgrowth, which can impair nutrient digestion, that can then lead additional factors that pave the way for the actual impairment.

Correlative variables 

Also known as variables having a “causal association” or “causal relationship”, these variables could be compared to the relationship between diet and heart disease. Both the mayo clinic and the NIH state that cardiovascular disease is caused by athero-sclerosis, secondary to poor diet and a lack of exercise, in the absence of evidence supporting direct causation.  

The primary correlative variables that pertain to this theory are Inflammatory conditions, and oxidative stress.

Oxidative stress is produced by metabolites referred to as Reactive Oxygen Species. ROS are chemically reactive molecules containing oxygen. Examples include oxygen ions and peroxides. Many within the medical field claim that these radical forms of oxygen “cause” disease. This theory contends that ROS are the primary correlative variable in chronic disease. These forms of oxygen have a protective role in cellular metabolism, but can also fail in providing the protective response, and instead damage a variety of cellular structures including genetic material.

Mechanisms of Impairment

Mechanisms of impairment typically lead to correlative responses such as elevated ROS production.

Causative agents include unsaturated proteins of stealth pathogens, ammine groups, the benzene ring, and a number of other pathogens that directly blocks the complex I protein within the mitochondrion’s inner membrane, a proton pumping complex that generates electron transfer from NADH to ubiquinone.

Without understanding the mechanism of impairment in chronic disease, one is left to dwell on correlative variables or predisposing factors, leading to a myopic perspective with regards to incorporating effective treatments.